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KMID : 0363819980320030199
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Korean Journal of Nuclear Medicine
1998 Volume.32 No. 3 p.199 ~ p.210
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Mucoiliary Clearance in Health and Disease
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Toyoharu Isawa
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Abstract
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Airway Mucus and Cilia
Mucociliary clearance is the first line of defense in the respiratory system. The mucus
overlying the epithelial surface of the respiratory tract is propelled upward toward the
larynx by coordinated beating of the cilia of the airway epithelium. The cilia line the
epithelium of the respiratory mucosa from the nasal passages to the terminal
bronchioles. In and distal to the terminal bronchiole the cilia are either poorly developed
or absents. Bronchial surface (the ciliary surface) is covered with mucus layer. Actually
the cilia are immersed in the periciliary fluid above which there is a mucus layer. By a
coordinated ciliary motion at the rate of about 1,000/min the mucus layer is normally
transported toward the oropharynx. Mucociliary clearance or transport is orchestrated by
interaction between the mucus layer and ciliary beats.
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